A similar phenotype to Camk2a-Cre;Rng105f/f mice, that is, long-term memory deficits with low steady-state EPSP and intact LTP, has been reported in other mice such as aged mice, prion-infected mice, chronic stressed mice, and Rett syndrome model (MeCP2-null) mice (Burke and Barnes, 2006; Mallucci et al., 2007; Kallarackal et al., 2013; Dani and Nelson, 2009). This evidence concerns the gene CAMK2A and Rett syndrome.