Some components of RNA granules have been reported to be associated with brain functions in disease, for example, fragile X mental retardation by FMRP deficiency and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) with aggregation of FUS/TLS and TDP-43 in RNA granules (Lenzken et al., 2014; Santos et al., 2014; Ling et al., 2013). Here, TARDBP is linked to amyotrophic lateral sclerosis.