Because Camk2a-Cre;Rng105f/f mice spent a comparable time to the other genotypes in the dark chamber before the foot shock, as well as showing normal anxiety-like behavior in the light/dark transition test (Figure 5—figure supplement 1A), the increased time in the dark chamber at 1 day and 1 week was considered not to be due to increased anxiety, but reduced long-term memory in Camk2a-Cre;Rng105f/f mice. The gene discussed is CAMK2A; the disease is Anxiety.