The importance of the C-X-C motif chemokine ligands CXCL-9 and CXCL-10 in mediating adaptive anti-tumour immunity is reinforced by their repeated identification in RNA-Sequencing transcriptome analysis of tumours with an “inflamed” immunophenotype predictive of response to immune checkpoint blockade [112, 113]. The gene discussed is CXCL9; the disease is neoplasm.