CD28 and neuroblastoma: Nishio and colleagues have demonstrated that Ad5Δ24 (an oncolytic adenovirus armed with the chemokine CCL-5/RANTES and the cytokine IL-15) could be used synergistically with 3rd generation human CAR T-cells (specific for GD2 and containing the CD28 and OX40 intracellular signalling domains) in a neuroblastoma-bearing immune compromised NOD SCID γcnull (NSG) mouse model.