In particular, second mitochondria-derived activator of caspases (Smac) mimetic compounds (SMCs), which, by countering inhibitor of apoptosis proteins (IAP) are able to sensitise tumour cells to apoptotic signalling induced by inflammatory cytokines, have been used in combination with OVs to induce potent bystander tumour cell death [198]. This evidence concerns the gene CD47 and neoplasm.