Approximately 20% of patients receiving anti-PD1 therapy, 30% receiving ipilimumab monotherapy, and 55% receiving ipilimumab and nivolumab (ipi/nivo) combination therapy will experience serious irAEs including dermatitis, colitis, hypophysitis, hepatitis, pneumonitis, nephritis and, more rarely, myocarditis [1]. The gene discussed is PDCD1; the disease is myocarditis.