In contrast to what was observed with atezolizumab in cohort II of IMvigor 210, responses appeared to be independent of PD-L1 tumor cell expression (objective response rates of 28.4%, 23.8%, and 16.1% were noted for tumor cell PD-L1 expression of >5%, > 1%, or <1% respectively). This evidence concerns the gene CD274 and neoplasm.