Preclinical studies in different cancer models showed that PI3K inhibitor could heighten the antitumor properties of toll-like receptor (TLR) ligands and was associated with increased accumulation of polyfunctional T cells that secreted multiple effector cytokines, including interferon-γ (IFN-γ), interleukin-17 (IL-17), and IL-2 [7]. This evidence concerns the gene IL17A and cancer.