Although the function of S100A14 in breast cancer remains to be elucidated, it has been suggested that S100A14 binds HER2 and modulates its phosphorylation, leading to HER2-stimulated cell proliferation, indicating that S100A14 may be a functional partner of HER2 in HER2-positive breast tumors [5]. The gene discussed is S100A14; the disease is breast neoplasm.