The role of UBE2T has so far been described in the DNA damage-induced monoubiquitination of Fanconi anemia complementation group D2 (FANCD2) [61], which is critical for the FA pathway to function [62], and in the polyubiquitination of BRCA1 through the interaction with the BRCA1/BRCA1-associated RING domain (BARD1) heterodimer, which results in BRCA1 degradation [56]. Here, FANCD2 is linked to Fanconi anemia complementation group D2.