CASP3 and neoplasm: Interestingly, LNT increased the cleaved Caspase 3 (C-Caspase 3) protein expression and decreased the cleaved PARP1 (C-PARP1) protein level, a hallmark of cell apoptosis occurrence [31, 32], confirming that LNT really promoted tumor cell apoptosis via caspase 3-dependent pathway.