Herein, weak p-ERK signals were seen in MCF-7 tumors, but LNT treatment remarkably enhanced the level of p-ERK1/2 protein in MCF-7 tumors (Figure 6A and 6B), contributing to significant proliferation inhibition observed in Ki67 staining of MCF-7 tumor tissues (Figure 5A and 5B). Here, MAPK3 is linked to neoplasm.