LGALS1 and neoplasm: In particular, we aimed to determine whether PSC-derived Galectin-1 promotes the proliferation, invasion, and metastasis of PDAC cells by inducing EMT through activating the NF-кB pathway, and to clarify the function of PSC-derived Galectin-1 as abridge between the desmoplastic stroma and cancer cells in the tumor microenvironment of PDAC.