AGO1 and neoplasm: In addition, AGO1 is located at chromosome 1p35-p34 and frequently lost in human malignant tumors, and rs636832 is located in the intron of AGO1, which might influence the conformation and function of proteins or the splicing of precursor miRNA [41], but no study reported the effect of rs636832 in AGO1 on tumor development, while current studies have not yet demonstrated a definite correlation between rs3742330 as well as rs7813 and GC invasion and metastasis.