Another study of 1,443 colon and rectal cancers demonstrated that a greater percentage (19-37%) of proximal colon cancers are MMRd compared to only 1.6% of rectal cancers, suggesting that rectal cancers may be less responsive to novel immunotherapies such as anti-PD-1 or anti-PD-L1 (checkpoint) inhibitors [12, 13]. The gene discussed is CD274; the disease is rectal cancer.