The prevalence of ALK rearrangement in patients with NSCLC has been found to range from 1.4% to 13% [22–25], and to be most common in those with a young age, a never or light smoking history, an abundant signet ring cell or solid pattern histology, and wild-type EGFR or KRAS gene mutations [22–32]. This evidence concerns the gene ALK and non-small cell lung carcinoma.