We chose to use MDA-MB-231 and MDA-MB-468 cells for determining miR-296-5p function as well as regulation of BOK and Mcl-1 as these cell lines have lower levels of miR-296-5p and higher levels of BOK and Mcl-1 compared to other breast cancer cell lines (Supplementary Figures 4A–4B). The gene discussed is BOK; the disease is breast cancer.