BAX and neoplasm: Given that GSK3 can act as a tumor promoter or suppressor and is reported to target other Bcl-2 family members including Bcl-2, Mcl-1 and BAX, it is plausible that stabilization of anti-apoptotic proteins (such as BCL2L12A) and degradation of pro-apoptotic proteins (such as BOK) by GSK-3 may induce tumor growth, while GSK3-mediated stabilization of pro-apoptotic protein (such as BAX) and degradation of anti-apoptotic proteins (such as Mcl-1) may lead to tumor suppression.