As shown in Figures 4D, 4E, COL17A1 expression directly affects activated form of Rac expression, indicating that COL17A1 regulate MMP9 expression likely through GTP-Rac1 activity in glioma, Together these data demonstrated that Increased Collagen XVII expression promotes the invasive activities of glioma cells. The gene discussed is AKT1; the disease is glioma.