As shown in Figures 4D, 4E, COL17A1 expression directly affects activated form of Rac expression, indicating that COL17A1 regulate MMP9 expression likely through GTP-Rac1 activity in glioma, Together these data demonstrated that Increased Collagen XVII expression promotes the invasive activities of glioma cells. This evidence concerns the gene COL17A1 and central nervous system cancer.