However, collectively, individual cell decisions lead to either initial expansion of wild type RUNX1 undifferentiated myeloblasts, followed by terminal granulocyte differentiation, as it happens in normal granulopoiesis, or incremental proliferation of undifferentiated RM8 myeloblasts, as it happens in t(8;21) acute myelogenous leukemia. Here, RUNX1 is linked to acute myeloid leukemia.