However, none of MTNR1B SNPs examined was found to be individually associated with clinical stage, tumor size, lymph node metastasis, distant metastasis, vascular invasion, Child-Pugh classification, prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, and cirrhosis. Here, MTNR1B is linked to metastatic malignant neoplasm in the lymph nodes.