Univariate and multivariate analyses demonstrated that tumor size at resection stage (HR: 1.949, 95% CI: 1.221-3.113, P=0.005), tumor number at recurrent stage (HR: 3.650, 95% CI: 1.869-7.127, P<0.001), AFP change after TACE (HR: 1.668, 95% CI: 1.204-2.311, P=0.002), cycles of TACE (HR: 0.896, 95% CI: 0.822-0.976, P=0.012), mRECIST response (HR: 0.540, 95% CI: 0.333-0.876, P=0.012) were independent predictors for OS. The gene discussed is AFP; the disease is neoplasm.