Significant differences in preoperative AFP level, pre-TACE AFP level and age were observed among the three groups (P < 0.05), whereas no significant difference was observed in gender, tumor number, tumor size, liver cirrhosis, differentiation, MVI, total bilirubin, albumin, CREA, PT, WBC, PLT and recurrence free survival (RFS) among 3 groups at resection stage or recurrence stage. The gene discussed is AFP; the disease is cirrhosis of liver.