Univariate and multivariate analyses showed that tumor size at resection stage (HR: 1.910, 95% CI: 1.180-3.092, P =0.008), tumor number at recurrent stage (HR: 4.004, 95% CI: 2.040-7.856, P<0.001), AFP change after TACE (HR: 1.650, 95% CI: 1.174-2.319, P=0.004), cycles of TACE (HR: 0.899, 95% CI: 0.821-0.985, P=0.022), mRECIST response (HR: 0.539, 95% CI 0.319-0.912, P=0.021) were independent predictors for RTDS. The gene discussed is AFP; the disease is neoplasm.