On the basis of these peptide screens, acidic ribosomal phosphoprotein (P0)-4, acidic ribosomal phosphoprotein (P0)-11, DNA topoisomerase 1 (full length)-1 and U1-SnRNP 68/70 KDa-1 peptides were selected for ELISA-based validation in an independent cohort of 40 SLE patients. Here, TOP1 is linked to systemic lupus erythematosus.