We observed that WT- and NPC-iNSCs showed no detectable expression of retroviral specific SOX2 and HMGA2, whereas WT- and NPC-hDFs on day 5 after infection exhibited high expression levels, suggesting that exogenous factors were silenced in both WT- and NPC-iNSCs. Here, HMGA2 is linked to nasopharyngeal carcinoma.