IRF4 and Miyoshi myopathy: Most of literatures suggested IRF4 up-regulation is correlated with poor prognosis [31, 32], we also analyzed public gene expression data and the correlations between the expression of IRF4 and the clinical parameters of MM patients, and found IRF4 in patients with end-stage disease was significantly higher than those patients with early-stage disease, which indicated that the increased expression of IRF4 is associated with poor prognosis.