SRSF1 interference reduced PVT1ΔE4 and elevated the full-length transcript of PVT1, SRSF1 decreased the inclusion and increased the skipping of exon 4 of full-length transcript and increased the relative expression of PVT1ΔE4 in ccRCC (Figure 6C). The gene discussed is SRSF1; the disease is nonpapillary renal cell carcinoma.