Taken together, our research demonstrates that PVT1 and its splicing variant PVT1ΔE4 could promote renal cancer cell proliferation and invasion at least partially by competitively binding with miR-200 family through regulating the expression of BMI1, ZEB1 and ZEB2, and overexpression of PVT1 may represent a biomarker of poor prognosis in ccRCC. This evidence concerns the gene ZEB1 and nonpapillary renal cell carcinoma.