It has been reported that hypoxia could promote chemoresistance in HCC through hypoxia induced multidrug-resistance related gene, such as multidrug resistance transporter P-glycoprotein [5], MDR1 (Multi-Drug Resistance Gene 1), MRP1 (Multidrug Resistance-associated Protein 1) and LRP (Lung Resistance-related Protein) [6]. This evidence concerns the gene ABCC1 and hepatocellular carcinoma.