In this respect, IL-31was found to stimulate in a mouse model the survival of myeloid progenitor cells [54], raising the possibility that in HL patients IL-31 induces neutrophilia, possibly in concert with other cytokines that have myelopoietic activity as CXCL8 [55], Since the WBC count is a prognostic factor included in the IPS score, both IL-31 and TSLP levels were higher in patients with an IPS>2, indicative of high risk disease. This evidence concerns the gene CXCL8 and Hodgkins lymphoma.