Significantly higher levels of sIL-31 and sTSLP (P=0.002, n=34/72, median 182 pg/ml for IL-31, P=0.03, n=25/48, median 167 pg/ml for TSLP) were detected in HL patients with an IPS >2 compared to those with IPS 0-2. This evidence concerns the gene TSLP and Hodgkins lymphoma.