At a non-cytotoxic concentration, F2 selectively suppressed the function of FPR1 (formyl peptide receptor 1) and the FPR1-mediated signaling pathway in a manner of a partial agonist in U87 cells [15], and it also inhibited the HIF-1 pathway in U251 glioma cells [16]. This evidence concerns the gene HIF1A and glioma.