PIGA and plasma cell myeloma: According to Hoppe’s work [34], 36% of 125I-pIgA (mouse myeloma producted) administrated by IV in rat, are transported as intact protein in bile over 3h post-injection; the pIgA reaches its highest concentration only 30 to 60 min after injection, and 80% of the total of 125I-pIgA are finally secreted in bile by 90 min.