The cell-specific effect of Ano1 on regulation of cell proliferation is further demonstrated by several studies showing that knockdown of Ano1 does not affect proliferation in HEK-293 cells [17], HNSCC BHY cells [25], colonic epithelial HT29 cells [26], pancreatic ductal adenocarcinoma cells [21], and gastric cancer cells [22]. The gene discussed is ANO1; the disease is pancreatic ductal adenocarcinoma.