Immunosuppressive Treg lymphocytes, M2 polarized tumor associated macrophages (TAM) and myeloid derived suppressor cells (MDSCs) prevail over immune effector CD8+ T cells, dendritic cells (DCs) and M1 polarized TAM in the tumor microenvironment, in blood and in lymphoid organs in both PDAC animal models and humans [15-23]. This evidence concerns the gene CD8A and neoplasm.