SMAD4 and cancer: The expression of hsa-miR-1260a augmented the percentage of PBMCs with regular calcium peaks and induced cells to form large clusters only when SMAD4 was also expressed (BxPC3-SMAD4+), suggesting that these hsa-miR-1260a-related effects require other cancer derived SMAD4-related co-factors, being SMAD4-related proteins potential candidates.