To determine if the inhibition of BRAFV600E and targeting of CDK4/6 (P16 downstream effector) was effective against these tumor cells, we tested a therapeutic approach using vemurafenib plus palbociclib treatment (Figure 6A), two FDA approved drugs for metastatic BRAFV600E-positive melanoma and metastatic breast cancer, respectively. Here, CDK4 is linked to neoplasm.