Importantly, we found an increased percentage of cells with chromosome 5 tetrasomy due to tetraploidy when RBMX was silenced during acute treatment with vemurafenib, suggesting that loss of function of this gene might play a crucial role in tetraploidization and exacerbates this phenotype. Also, the reduction of RBMX protein levels impacted on the down-regulation of phospho-AKT protein levels; these results might suggest the importance of RBMX protein not only to prevent DNA errors but also to inhibit AKT pathways which are fundamental to promote tumor cell survival and growth. This evidence concerns the gene RBMX and neoplasm.