IDH1 and anaplastic astrocytoma: Because all IDH mutant gliomas with an 8q gain harbor TP53 mutations (Table 2 and Figure 3A), these results suggest that remote recurrence depends on a TP53 mutation, is significantly associated with an 8q gain, and that the CNA contributes to a poor prognosis in diffuse and anaplastic astrocytomas, IDH-mutant.