Of note, a significant correlation (*p = 0.0068, Fisher exact test, n = 63 cases) between the combination of APC plus TP53 mutations and TUSC3 methylation (S3) was found in RanPlex CRC arrays, while there was no correlation of TUSC3 methylation with KRAS or BRAF mutations alone. This evidence concerns the gene KRAS and colorectal carcinoma.