We found that local application of our new modified delivery clinoptilolite-based system loaded with Carmustine on the skin of laboratory animals with artificially chemically induced skin cancers lead to decreased bcl-2 protein expression and cox-2 protein expression, so decreasing tumour survival chances and tumour aggressiveness, respectively, better than a reference Carmustine containing cream. This evidence concerns the gene PTGS2 and skin neoplasm.