In 2010, Jonsson and coworkers proposed a classification of cutaneous melanoma in four expression-based subtypes: the high immune subtype characterized by the elevated expression of immune genes; the normal-like (stromal) subtype, characterized by genes expressed in the surrounding normal cells; the MITF-high pigmentation, characterized by elevated expression of cell-cycle genes; the MITF-low proliferative subtype, characterized by a high expression of cell-cycle genes and a low expression of melanocyte differentiation genes [168]. The gene discussed is MITF; the disease is cutaneous melanoma.