GRIN2A and melanoma: The Transformation/Transcription Domain Associated Protein (TRRAP) gene, encoding the transformation/transcription domain-associated protein, was found to be mutated in 4% of melanomas [41]; the Glutamate Ionotropic Receptor NMDA Type Subunit 2A (GRIN2A) gene, encoding a glutamate receptor subunit epsilon-1, was found to be very frequently mutated (in approximately 25% of cases) [41].