Another recent study reported the recurrent mutation in PLCB4, occurring in about 4% of uveal melanomas (Table 3) [141]; importantly, PLCB4D630Y mutations are mutually exclusive with mutations in GNA11 and GNAQ, in line with the observation that PLCB4 is a canonical downstream target of GNA genes [141]. The gene discussed is PLCB4; the disease is uveal melanoma.