A recent study reported recurrent mutations of G-protein-coupled receptor CYSLTR2 (cysteinyl leokotriene receptor 2) exclusively occurring in uveal melanoma patients not displaying GNAQ, GNA11, and phospholipase C, beta 4 (PLCB4) mutations (in about 40% of these patients) [140]. The gene discussed is CYSLTR2; the disease is uveal melanoma.