Thus, cutaneous melanomas were characterized by frequent BRAF, CDKN2A, NRAS, and TP53 mutations; BRAF, NRAS, and NF1 mutations were frequent in acral melanomas, and splicing factor 3B subunit 1A (SF3B1) mutations were frequent in mucosal melanomas [91]. This evidence concerns the gene NF1 and cutaneous melanoma.