TET2 and TET3 are silenced in melanoma cells by epigenetic mechanisms triggered by TGF-β and mediated by DNA methyltransferase 3A (DNMT3A); these events play a functional role in the epithelial-to-mesenchymal transition (EMT) and in metastatic processes of melanomas [162]. The gene discussed is DNMT3A; the disease is melanoma.