Interestingly, a recent study based on the analysis of the transcriptome changes occurring in the transition from benign states to early-, intermediate-, and late-stage tumors allowed the identification of a high-risk subgroup of melanomas characterized by the deregulation of various genes regulating epigenetic machinery (“epigenetic gene signature”) and of the TP53 gene family (TP53, TP63, and TP73) [167]. Here, TP53 is linked to melanoma.