In contrast to these findings, a recent study by Giammaritoni and coworkers suggested that citokyne-induced killer (CIK) cells are able to kill both differentiated melanoma cells and putative melanoma CSCs (identified through a gene-transfer strategy involving the transduction with a lentiviral vector encoding the eGFP under expression control of the Oct4 promoter) [273]. The gene discussed is POU5F1; the disease is melanoma.