MC1R and melanoma: A recent study reported the analysis of 27 melanoma-prone families, showing: CDKN2AV126D mutation in 7/27; CDKN2AA148T was observed in 7/27 (this germline mutation was observed in 7/146 normal healthy blood donors); MC1R melanoma-associated polymorphism was detected in 78% of cases (and 66% in healthy donors); the MITFE318K mutant was observed in 7% of cases (and in 0.7% of healthy controls) [114].