CDK4 and neoplasm: The analysis of copy number alterations in the various tumor subtypes provided some interesting findings: Triple-WT had significantly more copy number alterations (CNAs) than the other tumor subtypes, these CNAs involving some known oncogenes such as Kit, PDGFRA, KDR, CDK4, CCND1, MDM2, and TERT; the BRAF mutant subtype was characterized by frequent CNAs of BRAF, MITF, PD-1, and PD-L1; NRAS mutant subtype was characterized by frequent NRAS amplifications [86].