The mutational pattern of mucosal melanoma is different from that observed in cutaneous melanomas: BRAF mutations are rare in mucosal melanomas (5–10%) [147], except for conjunctival melanomas (about 30%) [148]; NRAS mutations were observed in about 15–20% in mucosal melanomas [146]; NF1 mutations were frequently identified in mucosal melanomas (about 20% of cases) [147]; TERT promoter mutations were more rare in mucosal melanomas (about 5%) than in conventional cutaneous melanomas [147]. This evidence concerns the gene NRAS and mucosal melanoma.