Particularly, it was shown that Zinc finger E-box-binding homeobox 2 (ZEB2) modulates PTEN protein levels in a microRNA-dependent, protein coding-independent manner: ZEB2 downmodulation is commonly observed in human melanomas, and leads to an increased binding of some microRNAs to PTEN, with a consequent decrease of PTEN protein levels [62]. This evidence concerns the gene ZEB2 and melanoma.