Recent studies showed the presence of recurrent mutations of the EIF1AX and SF3B1 genes preferentially associated with chromosome 3 disomy; in fact, in a group of uveal melanoma patients with chromosome 3 disomy, the frequency of EIF1AX (48%) and SF3B1 (29%) was clearly higher than in patients with chromosome 3 monosomy, where EIF1AX and SFB31 mutations together exhibited a frequency of 5.7% (Table 3) [135]. The gene discussed is SF3B1; the disease is uveal melanoma.