It is of interest to note that the impact of EIF1AX and S3BF1 mutations on the prognosis of uveal melanomas is different, in that patients with tumors harboring EIF1AX mutations rarely demonstrated metastases and had a longer disease-free survival; on the other hand, patients with chromosome 3 disomy and with SF3B1 mutation had an enhanced metastatic risk compared with those without an SF3B1 mutation [138]. The gene discussed is SF3B1; the disease is uveal melanoma.