In this context, one study provided evidence that BRN-2 expression is stimulated in response to the activation of MAPK: in fact, it was shown that the expression of the oncogenic BRAFV600E mutant activates MEK, with consequent upregulation of BRN-2 levels, which in turn downregulates the cGMP-specific phosphodiesterase PRE5A with consequent increase in cytosolic free Ca2+, stimulating tumor invasivity [259]. This evidence concerns the gene MAP2K7 and neoplasm.