Thus, NF1 mutations were more frequent in desmoplastic than in non-desmoplastic melanoma (69% vs. 54%); furthermore, NF1 mutations were more frequent in pure desmoplastic melanoma than in mixed desmoplastic melanoma (80% vs. 56%); finally, non-head desmoplastic melanomas are more frequently NF1-mutated than head and neck-localized melanomas (88% vs. 55%) [155]. This evidence concerns the gene NF1 and desmoplastic melanoma.