These observations were also confirmed by the analysis of families with the predisposition to develop uveal melanoma: in these families, a germline truncating mutation in the BAP1 gene was observed; in these cases, the development of uveal melanoma was associated with the concomitant development of another tumor—either meningioma, lung cancer, or neuroendocrine carcinoma [132]. This evidence concerns the gene BAP1 and neoplasm.