As expected for common variants influencing cutaneous malignant melanoma risk, many of these loci contain genes involved in one of two heritable risk phenotypes for melanoma, such as pigmentation (MC1R, Tyrosinase (TYR), Solute Carrier Family 45 member 2 (SLC45A2), and Agouti Signaling Protein (ASIP)) and nevus counts (CDKN2A, TERT, and Phospholipase A2 Group 6 (PLA2G6)) [115]. The gene discussed is TYR; the disease is melanoma.