In addition to the abovementioned differences, a comparison of the mutational spectrum of spitzoid melanoma and conventional melanoma also showed many similarities between these two tumors: the mutational burden of spitzoid melanomas (747 ± 138 mutations) and conventional melanomas (758 ± 97 mutations) is highly comparable; there is a large overlap of driver mutations in spitzoid and conventional melanomas, with 66% of spitzoid melanomas displaying mutations affecting the MAPK pathway (37% BRAF mutations, 18% RAS mutations, and 11% NF1 mutations) [103]. This evidence concerns the gene BRAF and melanoma.