The SETDB1 gene is located on chromosome 1 at the level of the 1q21.3 region—a locus region with ten genes: this locus was identified as a melanoma susceptibility locus and contains two plausible genes for melanoma susceptibility: SETDB1 and Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) [43]. Here, SETDB1 is linked to melanoma.