In this context, initial studies have shown that spitzoid neoplasms lack some of the mutations typically observed in melanomas, such as NRAS, Kit, GNAQ or GNA11. A subset of spitzoid tumors were shown to display HRAS mutations or BRAF mutations, associated with BRCA1-associated protein 1 (BAP1) biallelic loss. The gene discussed is GNA11; the disease is melanoma.