Alcohol may initially activate EGFR/ErbB2 and/or induce ROS, which stimulate critical signaling components, such as p38 MAPK, Wnt/GSK3β/β-catenin, and TLR4/Nanog, as well as alter tumor microenvironment, resulting in the promotion of CSCs (Figure 1). The gene discussed is TLR4; the disease is neoplasm.