Alcohol exposure caused a drastic increase in the GFR (ErbB1 or HER1), ErbB2 (HER2), ErbB3 (HER3 CSC population and mammosphere formation in breast cancer cells overexpressing ErbB2, but it has a modest effect on breast cancer cells expressing low levels of ErbB2 [8,9]. This evidence concerns the gene RAPGEF5 and breast carcinoma.