CHEK2 and eye infection: Human and rabbit corneal explants have been used to study the inhibition of herpes viral replication using phosphonoacetic acid (PAA) and to demonstrate the role of Checkpoint Kinase 2 (Chk2) in promoting HSV-1 replication in the cornea, suggesting that Chk2 inhibitors could be used to treat HSV-1 ocular infection [103,104].