In a more recent study, the same authors have evaluated the drug combination of trametinib with panitumumab (MoAb inhibiting EGFR) and trastuzumab (Mab inhibiting HER2): these three-drug combinations were more active than the two-drug combinations reported above at inhibiting pancreatic cancer xenotransplants [183]. The gene discussed is EGFR; the disease is familial pancreatic carcinoma.