Thus, the interaction of PDAC cells with CAFs induces in these cells the methylation of some genes and, notably, of SOCS1 [200]; the inhibition of SOCS1 in fibroblast cells activates STAT3 and induces the release of insulin-like growth factor-1, required to sustain the growth of pancreatic cancer cells [201]. The gene discussed is SOCS1; the disease is familial pancreatic carcinoma.