CDK5 and familial pancreatic carcinoma: Eggers and coworkers have recently reported that CDK5 and its co-activators p35 and p39 are significantly overexpressed in more than 90%, 94% and 75%, respectively, compared with normal pancreas; the molecular mechanisms responsible for this overexpression are in part related to gene amplification, the genes encoding CDK5, p35 and p39 being amplified in 67% of pancreatic cancers [82].