According to the results of this study, it was concluded that PDAC-associated fibrosis cannot be considered only a physical barrier that reduces drug delivery to neoplastic tissue, that decreases the accessibility of immune cells to the tumor and promotes drug resistance, but also a force driving an elevated tissue mechanics, involved in the activation of important pathways, such as integrin-dependent signaling and YAP activation [39]. This evidence concerns the gene YAP1 and neoplasm.