KRAS and pancreatic adenocarcinoma: These alterations defined a core set of 12 cellular signaling pathways and processes that were altered in the majority (from 67–100%) of pancreatic adenocarcinomas: among them, the most notable were KRAS signaling, regulation of the G1/S cell cycle transition, TGF-β signaling, integrin signaling, regulation of cell invasion, homophilic cell adhesion and small guanine triphosphate (GTPase)-dependent signaling [8] (Figure 1).