Bao and coworkers have isolated a population of triple-marker-positive cells (CD44+/CD133+/EpCAM+) enriched in cancer stem cell-like cells from two pancreas cell lines and have shown that these cells preferentially express, compared to triple-marker-negative cells, some genes including BMi1, BMP4, BST2, BTG1, FolR1, FoxQ1, PRKAR1A, Sox4, TACTD2 and Wnt3a [163]. The gene discussed is PROM1; the disease is cancer.