A prototype of these oncogenes in pancreatic cancer is c-Myc for its overexpression observed in a part of pancreatic cancers, due, more frequently to enhanced transcriptional activity and, more rarely, to gene amplification; because of these events, the c-Myc core signaling is one of the pathways more frequently activated in pancreatic cancer [6]. The gene discussed is MYC; the disease is familial pancreatic carcinoma.