Interestingly, CD47 was involved also in the mediation of the anti-tumor activity of human exosomes engineered with siRNA or short hairpin RNA targeting KRASG12D: following injection into immunocompetent mice, these exosomes exhibited superior evasion of phagocytic clearance, compared to lysosomes, due to the expression on their surface of CD47, whose presence is required to mediate exosome escape from phagocytosis [187]. Here, CD47 is linked to neoplasm.