The type of analysis of KRAS mutations showed that the G12D mutant was the most frequent (48%), followed by G12V (31%) and G12R (21%); interestingly, 4% of PDACs display multiple KRAS mutations (some showing evidence of biallelic mutations), and these different KRAS mutations occurred in separate neoplastic cells in a single tumor [21]. This evidence concerns the gene KRAS and neoplasm.