Using the same experimental approach, these authors have also shown that triple-positive cells isolated from pancreatic cancer lines display a peculiar pattern of expression of several miRNAs: among them, miR-125b was found to be overexpressed in triple-positive cells, and its knockdown elicited a marked inhibition of tumor aggressiveness of these cells, consistent with the downregulation of CD44, EpCAM and EZH2 [164]. This evidence concerns the gene CD44 and familial pancreatic carcinoma.