AKT1 and cancer: In contrast to the reports of Nakaso and coworkers mentioned above [23], γ-tocotrienol is reported to induce a reduction in PI3K/Akt/ mechanistic target of rapamycin kinase (mTOR) signaling and a corresponding increase in the Bax/Bcl-2 ratio, cleaved caspase-3, and cleaved poly (ADP-ribose) polymerase (PARP) levels in these cancer cell lines.