Thus, targeting FGF1 and GJB1 could lead to the suppression of GBM invasion, whereas deactivation of ABCG2 and ALDH1A1 pathways could possibly impair GBM recurrence at the invasive margin by inhibiting the enrichment for stem-like subpopulations following chemo-radiation. The gene discussed is FGF1; the disease is glioblastoma.