Among inflammatory immune cells primarily implicated in the pathomechanisms of COPD (i.e., macrophages, neutrophils, monocytes, dendritic cells, natural killer cells, mast cells, T cells, and B cells), macrophages appear to play one of key roles as they are directly activated by cigarette smoke extract and secrete inflammatory proteins that coordinate the inflammatory process in COPD via effects on a number of immune cells including neutrophils, monocytes, and CD8+ lymphocytes [3,4,5]. This evidence concerns the gene CD8A and chronic obstructive pulmonary disease.