RORC and lymphoma: However, pharmacological inhibition of RORγt over a long duration is unlikely to reach 100% and it may be that thymocytes that still express functional RORγt may be able to prevent the occurrence of thymic changes, as was recently described for adult mice that were resistant to lymphoma development and that carried remnant RORγt transcripts due to incomplete disruption of the RORγ locus [63].