CD40LG and focal segmental glomerulosclerosis: In addition, we investigated whether the inhibition of CD40-CD40L interaction prevents the effects induced in cultured podocytes and in isolated glomeruli by plasma fractions purified from plasmapheresis eluates obtained from patients with post-tranplant recurrence of FSGS, and we measured the circulating levels of sCD40L in patients affected by FSGS compared to healthy subjects and to patients with membranous nephropathy.