Further support for this study comes from our previous observations [31] of lower tumoral MHC class I expression in hypoxic regions of the TME and studies in renal cell carcinomas which showed VHL mutations (i) conferred increased susceptibility to natural killer cell-mediated lysis [46] and (ii) identified several genes of the antigen-presentation pathway, including MHC class I and II genes, as potential targets of VHL in a RNA screen of interferon-stimulated responsive element (IRSE) regulated genes [9]. This evidence concerns the gene VHL and renal cell carcinoma.