The possibility of erroneous entry into the trial was addressed by using a robust diagnostic work-up (Table 1) collectively designed by a multidisciplinary team of clinicians, comprising pediatric gastroenterology, allergy, and immunology, and was based on careful symptom assessment by the investigators, with specific IgE testing and skin-prick testing (if assessed) to exclude any IgE-mediated CMA. This evidence concerns the gene IGHE and Allergy.