Data from the CommonMind Consortium project indicate that this variant is an eQTL for OPCML in the dorsolateral prefrontal cortex, and is associated with reduced expression (P=0.014 after correction for multiple testing).50OPCML has a role in opioid-binding and opioid receptor function51, 52 and is expressed in a range of neuronal tissues, primarily the cerebellum and cerebellar hemispheres.44, 45, 46OPCML has previous associations with body mass index,53 waist–hip ratio,54 visceral fat distribution55 and alcohol dependence,56 among other phenotypes. The gene discussed is OPCML; the disease is alcohol dependence.