Some of these MAAs, namely anti-SSA (Ro 60, Ro 52), anti-SSB (La), anti 75- and 100-kDa subunits of the nucleolar exosome complex (PM/Scl), and antibodies against 70- and 80-kDa subunits of a DNA-binding protein involved in double-stranded DNA repair (Ku) are commonly detected in patients suffering from idiopathic inflammatory myopathies associated with connective tissue diseases. This evidence concerns the gene CALR and connective tissue disorder.