Rate-correction for differences in clinical severity at baseline, APOE ɛ4 frequency, vascular pathology load, hippocampal atrophy, temporoparietal atrophy, glucose uptake in the temporal lobe, and basal forebrain atrophy did not eliminate the significant differences in favor of LMTM monotherapy for ADAS-cog, ADCS-ADL, or lateral ventricular volume. This evidence concerns the gene APOE and hippocampal atrophy.