CASP3 and acute myeloid leukemia: The retrospective acute myeloid leukaemia study to determine whether pharmacocopy is predictive of clinical response used 20 biobanked bone marrow samples; ten samples from patients achieving stable complete remission to induction therapy, and ten from non-responders to induction therapy.32, 33 The correlation coefficient (r) when examining the number of non-fragmented nuclei in each image after drug treatment was 0·99 with immunofluorescence against activated caspase-3 as a measure of cell death over samples from three patients, confirming the nuclear morphology readout (figure 1B).