Our recent study, entitled “Target Intestinal Microbiota to AlleviateDisease Progression in Amyotrophic Lateral Sclerosis”, has revealed apromising link of dysbiosis and aberrant intestine to disease progression in an ALS mousemodel with overexpression of human mutation gene superoxide dismutase 1(SOD1G93A)4.Mouse models expressing ALS-linked SOD1 mutations (e.g. SOD1G93A) effectivelyrecapitulate many features of the human disease, and have been extensively used to investigatepathogenic mechanisms of ALS6. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.