Thrombin cleaves fibrinogen to fibrin, which stabilizes platelets and clots.14Previous studies have demonstrated the association between baseline plasma FVIII activity in cancer patients, specifically in those with breast, colorectal, and cutaneous malignancies.15, 16However, the association between the genetic alterations in the gene encodingFVIII,VWF, andADAMTS13and long-term outcomes in patients with cutaneous melanoma has not been investigated in a large cohort of datasets. This evidence concerns the gene F8 and cancer.