VWF and melanoma: VWF is produced in all vascular endothelium; FVIII is expressed only in the sinusoidal and pulmonary vascular endothelium; ADAMTS13 is primarily synthesized in hepatic stellate cells,20but also found in trace amount in the vascular endothelium21, 22and platelets.23WhileVWF,FVIII, andADAMTS13mRNAs were identified in the melanoma tissues through RNA-Seq analysis, the protein expression has never been examined in tumor tissues.