While mutation rates inVWFare not associated with the long-term outcome in patients with melanoma, its plasma levels or the presence of ultra-large VWF on endothelial surface is shown to be important for the development of thrombosis and tumor metastasis.12, 13, 30, 31VWF is highly expressed in the vascular endothelium within the tumor, but not in the malignant melanoma cells themselves (Fig. 5andTable 2). The gene discussed is VWF; the disease is neoplasm.