EGFR and cancer: The EMT has been observed in association with acquired resistance to targeted inhibitors in a variety of oncogene-driven cancers, including EML4-ALK and EGFR mutant lung adenocarcinoma.38 EMT is observed as a morphologic change in cells, decreased epithelial markers (like E-cadherin) and upregulated mesenchymal markers (like vimentin), as well as increased migration and invasion properties of cells.