The clearest evidence to illustrate the similar physiologic functions has been shown in tumor-associated hypoglycemia induced by the pathophysiologic elevation of insulin10, 11 or IGF-2 from islet12 or non-islet tumor cells.13 Further evidence of the shared functionality of the systems was the early clinical experience in using IGF-1 as a therapy for type 2 diabetes.14 The gene discussed is IGF2; the disease is neoplasm.