NVP-AEW541 induced resistance.88 These resistant breast cancer cells have shifted their dependency from IGF-1R to an alternative receptor tyrosine kinase (RTK) Tyro-3 to regulate cell growth and survival.89 Further analysis indicated mTOR/p70S6K controlled the expression of Tyro-3 independently of AKT. The gene discussed is TYRO3; the disease is breast carcinoma.